2004 Titles

Chair: Siamon Gordon

• Details the relationships between chronic inflammation and cancer
• Covers the role in inflammation in tumour growth, angiogenesis and metastasis 
• Scientific discussions include research on inflammatory genes as risk factors for cancer initiation and progression
• Consideration of the current preventative and therapeutic strategies for cancer

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Anaphylaxis

Chair: Stephen Galli

• Covers the pathophysiology of different kinds of anaphylactic and anaphylactoid shock
• Presents epidemiological data on anaphylaxis
• Discusses problems relating to therapy, diagnosis and prevention

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Mammalian TRP channels as molecular targets

Chair: James W Putney Jr

• Covers the emergence of a new field in TRP channel research
• Includes presentations on the structure, function and regulation of mammalian TRP channels
• Provides evidence of the role of TRP channels in a variety of disease aetiologies
• Discusses the relevance of TRP channel research to drug development

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Reversible protein acetylation

Chair: Eric Verdin

• Brings to the fore the importance of reversible acetylation of proteins in relation to genetic regulation
• Discusses acetylation of histone proteins and the 'histone code hypothesis'
• Presents data influencing the current understanding of the enzymes involved in acetylation
• Covers the relevance of protein acetylation to new therepeutic possibilities for cancer

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Osteoarthritic joint pain

Chair: David Felson

• Covers the mechanisms that are believed to contribute to osteoarthritic joint pain
• Discusses the frequent disparity between signs and symptoms of OA joint pain
• Includes details of relevant cellular pathways and experimental models of pain control

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Pathological pain: from molecular to clinical aspects

Chair: Takao Kumazawa

• Explores the mechanisms of pain in normal and pathological states
• Discusses recent research on humoral messenger systems involving cytokines, neurotrophins, neuropeptides, inflammatory mediators and ion channels
• Highlights the importance of new technologies such as non-invasive brain imaging techniques in the study of pain
• Covers receptors and channels involved in nociception, neuropathic plasticity, plastic changes in opioid systems and opioid tolerance

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Biology of IGF-1: its interaction with insulin in health and malignant states

Chair: Derek LeRoith

• Highlights the importance of insulin-like growth factors to the pathogenesis of various cancers
• Discusses the similarities between receptors for insulin and IGF-1 and differences between their respective hormones
• Covers the clinical use of growth-hormone treatment 
• Focuses on important related conditions such as diabetes and obesity

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Inflammatory bowel disease: crossroads between microbes, epithelium and immune systems

Chair: Derek Jewell

• Covers the clinical and histological features of Crohn's disease and ulcerative colitis
• Discusses the role of the mucosal immune systems in the pathology of inflammatory bowel disease
• Brings to the fore the interplay between environment, host and bacterial genetics in this range of autoimmune disorders
• Investigates available treatment options and prevention methods 

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