2005 Titles

Nuclear organization in development and disease NF264

Chair: Robert D Goldman

• Reveals leading scientists' understanding of the nuts and bolts within the nucleus
• Discusses the structure of the nuclear envelope, the nuclear pores and regulation of membrane-related processes
• Highlights the importance of nuclear integrity to health, and the various diseases associated with mutation in the Lamin genes
• Presents data influencing our understanding of the role of nuclear structure in gene expression

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Stem cells: nuclear reprogramming and therapeutic applications NF265

Chair: John Gearhart

• Discusses the nature of stem cells, and their potential medical uses
• Reveals interesting insights into the legislation surrounding stem cells in different countries
• Presents data from researchers of stem cells from adults and embryos
• Features animated discussion between leading scientists in the field of stem-cell research, including Weissman, Solter, Evans, Wilmut, Gurdon and more... 

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The hERG cardiac potassium channel: structure, function and long QT syndrome NF266

Chair: Michael C Sanguinetti

• The role of the hERG cardiac potassium channel in long QT syndrome
• The relevance of hERG to drug development
• The structure and function of this ion channel
• The regulatory authority perspectives aimed at a better understanding of hERG channel structure and function

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The genetics of autoimmunity NF267

Chair: Abul Abbas

• Covers the interplay between inherited susceptibility genes and environmental triggers in autoimmune disease
• Discusses the development of tools for whole-genome scans that can be used to research human-genome data for susceptibility genes
• Focuses on the use of SNP technologies in assessing susceptibility loci
• Highlights important recent discoveries of shared susceptiblity loci between different autoimmune diseases

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Molecular mechanisms influencing aggressive behaviours NF268

Chair: Donald Pfaff

• Features insights into the neuroanatomy and related neurophamacology of aggressive behaviours
•  Details the use of new molecular genetic techniques to explore mechanisms of aggression in novel ways
• Presents data on sex differences in aggression and related hormonal effects, specific genes for neurotransmitters, neuropeptides, and nitric oxide
• Discusses the implications of animal studies on aggression for understanding human behaviour

Signalling networks in cell shape and motility NF269

Chair: Gary Borisy

• Discusses the organizing principles behind cell shape change
• Covers the concept of 'master switches' within different cell types
• Explains how extracellular signals interpreted by the cell can activate intracellular processes
• Includes discussion of the role of the extracellular matrix in cell movement and internal signalling pathways
• Proposes mechanisms for the ways by which pathogens subvert cellular systems in order to stimulate or block their uptake

Percept, decision, action: bridging the gaps NF270

Chair: Ranulfo Romo

• Addresses how the brain uses sensory information to develop and decide upon the appropriate action and how the brain determines the appropriate action to optimize the collection of new sensory information
• Discusses how percepts are built up in cortex and how judgments of the percept are made
• Considers information flow within and between cortical region
• Reviews how decisions made about the percept are subsequently acted upon
• Covers the interaction between the predicted or expected sensation and actual incoming flow of sensory signals

Signalling pathways in acute oxygen sensing NF272

Chair: Michael Duchen

• Considers the controversial identity of the oxygen sensor common to all cells
• Encompasses the main players, NADPH oxidases, cytochrome p450 enzymes and mitochondria
• Discusses the involvement of ROS and complex III of electron transport chain in oxygen sensing
• Covers the conceptual problems with mitochondrial inhibition in response to hypoxia
• Includes discussion of the roles of potassium channels, and calcium entry via L-type channels

Epithelial anion transport in health and disease: the role of the SLC26 transporters family NF273

Chair: Michael Welsh

• Covers the mechanisms controlling the passage of chloride, sulphate, bicarbonate and oxalate ions across the cell membrane
• Focuses specifically on the recently discovered SLC26 transporter family
• Is pertinent to the study of diseases such as cystic fibrosis
• Contains discussions which identify new areas of research where data are urgently needed

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This page was last updated on 20 December 2005