Contents

Symposium on Sodium channels and neuronal hyperexcitability, held at the Novartis Foundation, London, 14-16 November 2000

Editors: Gregory Bock (Organizers) and Jamie A. Goode

This symposium is based on a proposal made by John Wood and Stephen Waxman in conjunction with the Yale-London Collaboration

Stephen G. Waxman
Chairs introduction: Sodium channels and neuronal dysfunction-emerging concepts, converging themes

Richard D. Keynes
Studies of multimodal gating of the sodium channel
Abstract
Discussion

Richard Horn
Molecular basis for function in sodium channels
Abstract
Discussion

Stephen G. Waxman, Theodore R. Cummins, Joel A. Black and Sulayman Dib-Hajj
Diverse functions and dynamic expression of neuronal sodium channels
Abstract
Discussion

Wayne E. Crill, Peter C. Schwindt and John C. Oakley
Enhanced transmission of glutamate current flowing from the dendrite to the soma in rat neocortical layer 5 neurons
Abstract
Discussion

Miriam H. Meisler, Jennifer A. Kearney, Leslie K. Sprunger, Bryan T. MacDonald, David A. Buchner and Andrew Escayg
Mutations of voltage-gated sodium channels in movement disorders and epilepsy

Abstract
Discussion

Louis Ptacek
Channelopathies: episodic disorders of the nervous system
Abstract
Discussion

Jeffrey L. Noebels
Sodium channel gene expression and epilepsy
Abstract
Discussion

Lori L. Isom
Beta subunits: players in neuronal hyperexcitability?
Abstract
Discussion

Stuart Bevan and Nina Storey
Modulation of sodium channels in primary afferent
Abstract
Discussion

John N. Wood, Armen N. Akopian, Mark Baker et al
Sodium channels in primary sensory neurons: relationship to pain states
Abstract
Discussion

Michael M. Segal
Sodium channels and epilepsy electrophysiology
Abstract
Discussion

Gary R. Strichartz, Zhongren Zhou, Catherine Sinnott and Alla Khodorova
Therapeutic concentrations of local anaesthetics unveil the potential role of sodium channels in neuropathic pain
Abstract
Discussion

William A. Catterall
Molecular mechanisms of gating and drug block of sodium
Abstract
Discussion

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