Contents

Symposium on 'In silico' simulation of biological processes, held at the Novartis Foundation, London, 27-29 November 2001

Editors: Gregory Bock (Organizer) and Jamie A. Goode

This symposium is based in a proposal made by Dr Paul Herrling

Dennis Noble
Chair's introduction

Andrew D. McCulloch and Gary Huber
Integrative biological modelling in silico
Abstract
Discussion

Mike Giles
Advances in computing, and their impact on scientific computing
Abstract
Discussion

David Krakauer
From physics to phenomenology. Levels of description and levels of selection
Abstract
Discussion

Philip K. Maini
Making sense of complex phenomena in biology
Abstract
Discussion

Michael Ashburner and Suzanna Lewis
On ontologies for biologists: the Gene Ontology-untangling the web
Abstract
Discussion

General discussion I 
Model Validation

Minoru Kanehisa
The KEGG database
Abstract
Discussion

Shankar Subramaniam and the Bioinformatics Core Laboratory
Bioinformatics of cellular signalling
Abstract
Discussion

General discussion II
Standards of communication
Semantics of intercommunicability

Raimond L. Winslow, Patrick Helm, William Baumgartner Jr., Srinivas Peddi, Tilak Ratnanather, Elliot McVeigh and Michael I. Miller
Imaging-based integrative models of the heart: closing the loop between experiment and simulation
Abstract
Discussion

General discussion III
Modelling Ca²⁺ signalling

Leslie M. Loew
The Virtual Cell project
Abstract
Discussion

Thomas Simon Shimizu and Dennis Bray
Modelling the bacterial chemotaxis receptor complex
Abstract
Discussion

Denis Noble
The heart cell in silico: successes, failures and prospects
Abstract
Discussion

General discussion IV

P.J. Hunter, P.M.F. Nielsen and D. Bullivant
The IUPS Physiome Project
Abstract
Discussion

Jeremy M. Levin, R. Christian Penland, Andrew T. Stamps and Carolyn R. Cho
Using in silico biology to facilitate drug development
Abstract
Discussion

Final discussion
Is there a theoretical biology?

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