Contents

Novartis Foundation symposium on Nuclear organization in development and disease, held at the Novartis Foundation, London, 27–29 January 2004

Editors: Derek J. Chadwick (Organizer) and Jamie Goode

This symposium is based on a proposal made by Colin Stewart

Robert Goldman 
Chair’s introduction

Robert D. Goldman, Anne E. Goldman and Dale K. Shumaker 
Nuclear lamins: building blocks of nuclear structure and function
Abstract
Discussion

Brian Burke, Catherine Shanahan, Davide Salina and Melissa Crisp 
Aspects of nuclear envelope dynamics in mitotic cells
Abstract
Discussion

Howard J. Worman 
Components of the nuclear envelope and their role in human disease
Abstract
Discussion

Katherine L. Wilson, James M. Holaska, Rocio Montes de Oca, Kathryn Tifft, Michael Zastrow, Miriam Segura-Totten, Malini Mansharamani and Luiza Bengtsson 
Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease
Abstract
Discussion

Eric C. Schirmer, Laurence Florens, Tinglu Guan, John R. Yates III and Larry Gerace 
Identification of novel integral membrane proteins of the nuclear envelope with potential disease links using subtractive proteomics
Abstract
Discussion

Rabah Ben Yaou, Antoine Muchir, Takuro Arimura, Catherine Massart, Laurence Demay, Pascale Richard and Gisèle Bonne 
Genetics of laminopathies
Abstract
Discussion

Kristen Nowak, Karl McCullagh, Ellen Poon and Kay E. Davies 
Muscular dystrophies related to the cytoskeleton/nuclear envelope
Abstract
Discussion

M. J. Grattan, C. Kondo, J. Thurston, P. Alakija, B. J. Burke, C. Stewart, D. Syme and W. R. Giles 
Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy
Abstract
Discussion

Angela Taddei, Marc R. Gartenberg, Frank R. Neumann, Florence Hediger and Susan M. Gasser 
Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for Sir-mediated repression 
Abstract
Discussion

Corinne Vigouroux and Jacqueline Capeau 
A-type lamin-linked lipodystrophies 
Abstract
Discussion

Jean-Pierre Julien, Stephanie Millecamps and Jasna Kriz
Cytoskeletal defects in amyotrophic lateral sclerosis (motor neuron disease)
Abstract
Discussion

Shurong Huang, Brian K. Kennedy and Junko Oshima
LMNA mutations in progeroid syndromes
Abstract
Discussion

Daniel A. Starr and Min Han 
A genetic approach to study the role of nuclear envelope components in nuclear positioning
Abstract
Discussion

General discussion I

Ayelet Margalit, Jun Liu, Alexandra Fridkin, Katherine L. Wilson and Yosef Gruenbaum 
A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development
Abstract
Discussion

Serguei Kozlov, Leslie Mounkes, Dedra Cutler, Terry Sullivan, Lidia Hernandez, Nicolas Levy, Jeff Rottman and Colin L. Stewart 
Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy
Abstract
Discussion

Jan Lammerding and Richard T. Lee 
The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C-deficient cells
Abstract
Discussion

Robert Goldman 
Chair’s summing-up

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