Contents

Symposium on Heart failure: molecules, mechanisms and therapeutic targets, held at the Novartis Foundation, 26–28 April 2005 
Editors: Gregory Bock (Organizer) and Jamie Goode 
This symposium is based on a proposal made by Eric N. Olson 

Eric N. Olson, Johannes Backs and Timothy A. McKinsey Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation
Abstract
Discussion

Hiroshi Akazawa, Yunzeng Zou and Issei Komuro A nov el mechanism of mechanical stress-induced hypertrophy
Abstract
Discussion

N. de Jonge, M. J. Goumans, Daan Lips, Rutger Hassink, Eva J. Vlug, Roy van der Meel, Christopher Donald Emmerson, Joppe Nijman, Leon de Windt and Pieter A. Doevendans Controlling cardiomyocyte survival
Abstract
Discussion

Mona Nemer, Nassim Dali-Youcef, Hao Wang, Anne Aries and Pierre Paradis Mechanisms of angiotensin II-dependent progression to heart failure 
Abstract
Discussion 

Matthew R. Taylor and Michael R. Bristow Alterations in myocardial gene expression as a basis for cardiomyopathies and heart failure
Abstract
Discussion

Julie R. McMullen and Seigo Izumo Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy
Abstract
Discussion

Anthony J. Muslin and Brian DeBosch Role of Akt in cardiac growth and metabolism
Abstract
Discussion 

Andrew R. Marks novel therapy for heart failure and exercise-induced ventricular tachycardia based on ‘fixing’ the leak in ryanodine receptors
Abstract
Discussion

Guoxiang Chu and Evangelia G. Kranias Phospholamban as a therapeutic modality in heart failure
Abstract
Discussion

Mitsuhiro Kamisago, Joachim P. Schmitt, Dennis McNamara, Christine Seidman and Jonathan G. Seidman Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure
Abstract
Discussion 

Pascal J. E. Lafontant and Loren J. Field The cardiomyocyte cell cycle
Abstract
Discussion 

Carmen Urbich, Lothar Rössig and Stefanie Dimmeler Restoration of cardiac function with progenitor cells
Abstract
Discussion

Maria Paola Santini, Nadine Winn and Nadia Rosenthal Signalling pathways in cardiac regeneration
Abstract
Discussion 

Kenneth R. Chien Beyond small molecule drugs for heart failure: prospects for gene therapy 
Abstract
Discussion 

Michael D. Schneider Dual roles of telomerase in cardiac protection and repair 
Abstract
Discussion

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