Contents

Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17–19 May 2005
Editors: Gregory Bock (Organizer) and Jamie Goode
This symposium is based on a proposal made by Robert West and Gino van Heeke

Richard Peto and Richard Doll The hazards of smoking and the benefits of stopping 
Abstract
Discussion

Ian Stolerman Animal models for nicotine dependence
Abstract
Discussion

Robert West Defining and assessing nicotine dependence in humans
Abstract
Discussion

Uwe Maskos, Sylvie Granon, Philippe Faure and Jean-Pierre Changeux Nicotinic acetylcholine receptors functions in the CNS investigated with a novel method of sterotaxic gene re-expression in knockout mice 
Abstract
Discussion

Marina R. Picciotto Nicotine-mediated activation of signal transduction pathways
Abstract
Discussion

David Balfour Complementary roles for the accumbal shell and core in nicotine dependence
Abstract
Discussion 

Christian Heidbreder The dopamine D3 system: new opportunities for dopamine-based reward
Abstract
Discussion

Athina Markou Pathways and systems involved in nicotine dependence 
Abstract
Discussion

Arthur L. Brody Localizing tobacco dependence pathways with functional brain imaging
Abstract
Discussion

Caryn Lerman Pharmacogenetic approach to nicotine dependence treatment
Abstract
Discussion

Robert Walton Pharmacogenomics and smoking cessation
Abstract
Discussion

Peter Hajek What limits the efficacy of current nicotine replacement therapies?
Abstract
Discussion 

Saul Shiffman, Stuart Ferguson and Deborah Scharf Exploring behavioural mechanisms of icotine replacement therapy for smoking cessation
Abstract
Discussion

Rachel F. Tyndale and Edward M. Sellers Modifying the metabolism of nicotine as a therapeutic strategy
Abstract
Discussion

William A. Corrigall Challenges in discovery and development of pharmacotherapies for tobacco addiction
Abstract
Discussion


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